CELL LONGEVITY

MOLECULES WITH TECHNOLOGY

INTEGRATIVE PROTOCOLS

INTEGRATIVE PROTOCOLS
ASSOCIATED TO
DERMATOLOGICAL
MELASMA TREATMENTS

The skin is constantly exposed to DNA-damaging environmental perturbations and requires
biological mechanisms to protect against and repair the damages:

1.
Increasing of epidermal layers.

2.
DNA-cell repair mechanisms and apoptosis.

3.
Antioxidant and enzymatic protection.

4.
Melanin production stimulation.

The photodamages induced by UVRays are signals that increase melanogenesis. An excess of Reactive Oxygen Species, such as Superoxide anion, stimulates melanocytes metabolism.

VARIOUS
HYPERPIGMENTATIONS

1. PIH, post inflammatory hyperpigmentations

Inflammation plays a main role in induced hyperpigmentations:

• Even the most common cause of hyperpigmentation: sunlight exposure of skin, is more likely a postinflammatory response to UV damage to skin (Gilchrest et al., 1998; Abdel-Malek and Kadekaro, 2006).
  
• This results through several mechanisms. Among them is direct stimulation of melanocytes by inflammatory mediators such as IL-1-α, endothelin-1, and/or stem cell factor (Sriwiriyanont et al., 2006).

These cells are often retained in the upper dermis . Thus, PIH can be a very long-lived problem for the skin.

2. Actinic lentigos

Hyperpigmented spots are due to a chronic exposure to UVR and result from a chronic inflammation.

3. Melasma

Melasma is a chronic skin condition characterized by hyperpigmentation on sun-exposed facial skin, cheeks, forehead, nose, and supralabial regions.
Melasma is often attributed to UVR exposure, pregnancy, oral contraceptives, deseases, some cosmetic formulations.

Indications

Regenerativ protocols associated to dermatological treatments.

Actions

• Interfering with the pathways that synthesize melanin.
• Powerful Antioxydant action, to interfer with Anion Superoxide.
• Decreasing the melanine transfer to the top most layers of the skin.

Results

Significant improvement of the pigmentation.

RETARGETING MELASMA
PROTOCOL IN INTEGRATIVE
DERMATOLOGY

Renophase PhotoRegeneration
Combines Melasma Procedure with LED Red Light session, providing :

• An amplification of the results and boost of Red Light action on pro-inflammatory cytokines. The melanin produced during an inflamatory event can enter the dermis where it is engulfed by macrophages, producing “melanophages” (Halder and Nordlund, 2006). UVR increases plasmin activity in keratinocytes, wich leads to an increased secretion of cytokine, melanocytic-stimulating mediators, such as arachidonic acid and alpha-melanocyte stimulating hormone, that stimulates the synthesis and the transfer of melanin.

BEFORE and AFTER
PROCEDURES

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KLOTHO and
TRANEXAMIQUE ACID
new approch in Melasma treatment

• Hight Protection from oxydative stress, control of melanogenesis.

Many international studies have demonstrated the efficacy of topical treatment with Tranexamic acid, on melasma.The results indicate that TA inhibits melanin synthesis not by acting directly on melanocytes, but by inhibiting melanogenesis activators.

Tranexamic Acid appears to be as effective as topical hydroquinone.

Discover prescription for hyperpigmentation disorder

RED LIGHT 633NM IN
RENOPHASE PHOTOREGENERATION